Using Osmolarity to Diagnose Dry Eye: A Compartmental Hypothesis and Review of Our Assumptions
書誌事項
- 公開日
- 2002
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1007/978-1-4615-0717-8_153
- 公開者
- Springer US
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説明
Two major forms of dry eye exist, aqueous-deficient (ADDE) and evaporative (EDE). 1 A major inflammatory component is also recognised. 1-2 The two forms have global features in common that identify them as dry eye, but do not specify cause. Of these, tear hyperosmolarity arises either as a result of evaporation in the presence of reduced tear flow, or excessive evaporation in the presence of a normal flow rate. Hyperosmolarity may contribute to inflammatory processes at the ocular surface by causing epithelial damage, possibly inducing cytokine release from epithelial cells. 5 Inflammation in dry eye is otherwise due to a complex process including autoimmune lacrimal gland and duct destruction, and release of inflammatory mediators from the gland and conjunctiva into tears. Tear instability results from a loss of stabilizing components of tears, such as mucin and lipocalin. Ocular surface damage may result from tear hyperosmolarity, proinflammatory mediators in the tears, and decreased lubrication between the lids and globe. These factors are probably responsible for many symptoms of dry eye..
収録刊行物
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- Advances in Experimental Medicine and Biology
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Advances in Experimental Medicine and Biology 506 1087-1095, 2002
Springer US
