Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury
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- Yuhei Kirita
- Division of Nephrology, Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110;
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- Haojia Wu
- Division of Nephrology, Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110;
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- Kohei Uchimura
- Division of Nephrology, Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110;
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- Parker C. Wilson
- Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110;
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- Benjamin D. Humphreys
- Division of Nephrology, Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110;
抄録
<jats:title>Significance</jats:title> <jats:p>Single nucleus RNA sequencing revealed gene expression changes during repair after acute kidney injury. We describe a small population of proximal tubule cells that fail to repair (FR-PTCs). Since this subpopulation expresses abundant proinflammatory and profibrotic genes, it may represent a new therapeutic target to improve repair and reduce fibrosis after AKI.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 117 (27), 15874-15883, 2020-06-22
Proceedings of the National Academy of Sciences