Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

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<jats:title>Abstract</jats:title><jats:p>NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD<jats:sup>+)</jats:sup> precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD<jats:sup>+</jats:sup> in whole blood demonstrated that NRPT significantly increases the concentration of NAD<jats:sup>+</jats:sup> in a dose-dependent manner. NAD<jats:sup>+</jats:sup> levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD<jats:sup>+</jats:sup> levels was sustained throughout the entire 8-week trial. NAD<jats:sup>+</jats:sup> levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD<jats:sup>+</jats:sup> levels sustainably.</jats:p>

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