New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics
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- Si-Yuan Pan
- School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
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- Shu-Feng Zhou
- College of Pharmacy,University of South Florida, Tampa, FL 33612, USA
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- Si-Hua Gao
- School of basic medicine, Beijing University of Chinese Medicine, Beijing 100102, China
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- Zhi-Ling Yu
- School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
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- Shuo-Feng Zhang
- School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
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- Min-Ke Tang
- School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
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- Jian-Ning Sun
- School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
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- Dik-Lung Ma
- Department of Chemistry, Hong Kong Baptist University, Hong Kong
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- Yi-Fan Han
- Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong
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- Wang-Fun Fong
- School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
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- Kam-Ming Ko
- Division of Life Science, Hong Kong University of Science & Technology, Hong Kong
書誌事項
- 公開日
- 2013
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2013/627375
- 公開者
- Wiley
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説明
<jats:p>With tens of thousands of plant species on earth, we are endowed with an enormous wealth of medicinal remedies from Mother Nature. Natural products and their derivatives represent more than 50% of all the drugs in modern therapeutics. Because of the low success rate and huge capital investment need, the research and development of conventional drugs are very costly and difficult. Over the past few decades, researchers have focused on drug discovery from herbal medicines or botanical sources, an important group of complementary and alternative medicine (CAM) therapy. With a long history of herbal usage for the clinical management of a variety of diseases in indigenous cultures, the success rate of developing a new drug from herbal medicinal preparations should, in theory, be higher than that from chemical synthesis. While the endeavor for drug discovery from herbal medicines is “experience driven,” the search for a therapeutically useful synthetic drug, like “looking for a needle in a haystack,” is a daunting task. In this paper, we first illustrated various approaches of drug discovery from herbal medicines. Typical examples of successful drug discovery from botanical sources were given. In addition, problems in drug discovery from herbal medicines were described and possible solutions were proposed. The prospect of drug discovery from herbal medicines in the postgenomic era was made with the provision of future directions in this area of drug development.</jats:p>
収録刊行物
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- Evidence-Based Complementary and Alternative Medicine
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Evidence-Based Complementary and Alternative Medicine 2013 1-25, 2013
Wiley
