Chlorogenic Acid Exhibits Cholesterol Lowering and Fatty Liver Attenuating Properties by Up‐regulating the Gene Expression of PPAR‐α in Hypercholesterolemic Rats Induced with a High‐Cholesterol Diet

DOI Web Site Web Site 被引用文献4件
  • Chun‐Wai Wan
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR China
  • Candy Ngai‐Yan Wong
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR China
  • Wing‐Kwan Pin
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR China
  • Marcus Ho‐Yin Wong
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR China
  • Ching‐Yee Kwok
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR China
  • Robbie Yat‐Kan Chan
    Programme of Food Science and Technology, Division of Science and Technology BNU‐HKBU United International College Zhuhai China
  • Peter Hoi‐Fu Yu
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR China
  • Shun‐Wan Chan
    Food Safety and Technology Research Centre, Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hong Kong SAR China

書誌事項

公開日
2012-06-06
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/ptr.4751
公開者
Wiley

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説明

<jats:p>Hypercholesterolemia is a major risk factor for the development of cardiovascular disease and nonalcoholic fatty liver disease. Natural compounds have been proved to be useful in lowering serum cholesterol to slow down the progression of cardiovascular disease and nonalcoholic fatty liver disease. In the present study, the hypocholesterolemic and hepatoprotective effects of the dietary consumption of chlorogenic acid were investigated by monitoring plasma lipid profile (total cholesterol, triglycerides, high‐density lipoprotein and low‐density lipoprotein) in Sprague–Dawley rats fed with a normal diet, a high‐cholesterol diet or a high‐cholesterol diet supplemented with chlorogenic acid (1 or 10 mg/kg/day p.o.) for 28 days. Chlorogenic acid markedly altered the increased plasma total cholesterol and low‐density lipoprotein but decreased high‐density lipoprotein induced by a hypercholesterolemic diet with a dose‐dependent improvement on both atherogenic index and cardiac risk factor. Lipid depositions in liver were attenuated significantly in hypercholesterolemic animals supplemented with chlorogenic acid. It is postulated that hypocholesterolemic effect is the primary beneficial effect given by chlorogenic acid, which leads to other secondary beneficial effects such as atheroscleroprotective, cardioprotective and hepatoprotective functions. The hypocholesterolemic functions of chlorogenic acid are probably due to the increase in fatty acids unitization in liver via the up‐regulation of peroxisome proliferation‐activated receptor α mRNA. Copyright © 2012 John Wiley & Sons, Ltd.</jats:p>

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