13- <i>cis</i> -retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice
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- James Crandall
- E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452; and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01655
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- Yasuo Sakai
- E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452; and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01655
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- Jinghua Zhang
- E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452; and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01655
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- Omanand Koul
- E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452; and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01655
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- Yann Mineur
- E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452; and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01655
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- Wim E. Crusio
- E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452; and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01655
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- Peter McCaffery
- E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452; and Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01655
書誌事項
- 公開日
- 2004-03-29
- DOI
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- 10.1073/pnas.0306336101
- 公開者
- Proceedings of the National Academy of Sciences
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説明
<jats:p> The active component of the acne drug Accutane is 13- <jats:italic>cis</jats:italic> -retinoic acid (RA), and it is highly teratogenic for the developing central nervous system. Very little is known, however, regarding the effect of this drug on the adult brain. Regions of the brain that may be susceptible to RA are those that continue to generate new neurons. In the adult mouse, neurogenesis is maintained in the hippocampus and subventricular zone. This report demonstrates that a clinical dose (1 mg/kg/day) of 13- <jats:italic>cis</jats:italic> -RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13- <jats:italic>cis</jats:italic> -RA. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 101 (14), 5111-5116, 2004-03-29
Proceedings of the National Academy of Sciences