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- Annemarthe G. van der Veen
- Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142;
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- Hidde L. Ploegh
- Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142;
説明
<jats:p>The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) that are part of this family adopt the β-grasp fold that is characteristic of its founding member ubiquitin (Ub). Although structurally related, UBLs regulate a strikingly diverse set of cellular processes, including nuclear transport, proteolysis, translation, autophagy, and antiviral pathways. New UBL substrates continue to be identified and further expand the functional diversity of UBL pathways in cellular homeostasis and physiology. Here, we review recent findings on such novel substrates, mechanisms, and functions of UBLs.</jats:p>
収録刊行物
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- Annual Review of Biochemistry
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Annual Review of Biochemistry 81 (1), 323-357, 2012-07-07
Annual Reviews
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詳細情報 詳細情報について
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- CRID
- 1362262945427853056
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- ISSN
- 15454509
- 00664154
- http://id.crossref.org/issn/00664154
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- データソース種別
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- Crossref