Memory CD4 T Cells That Express CXCR5 Provide Accelerated Help to B Cells
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- Megan K. L. MacLeod
- *Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Health, Denver, CO 80206;
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- Alexandria David
- *Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Health, Denver, CO 80206;
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- Amy S. McKee
- *Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Health, Denver, CO 80206;
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- Frances Crawford
- *Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Health, Denver, CO 80206;
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- John W. Kappler
- *Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Health, Denver, CO 80206;
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- Philippa Marrack
- *Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Health, Denver, CO 80206;
Abstract
<jats:title>Abstract</jats:title><jats:p>CD4 T cell help for B cells is critical for effective Ab responses. Although many of the molecules involved in helper functions of naive CD4 T cells have been characterized, much less is known about the helper capabilities of memory CD4 T cells, an important consideration for the design of vaccines that aim to prime protective memory CD4 T cells. In this study, we demonstrate that memory CD4 T cells enable B cells to expand more rapidly and class switch earlier than do primary responding CD4 T cells. This accelerated response does not require large numbers of memory cells, and similar numbers of primary responding cells provide less effective help than do memory cells. However, only memory CD4 T cells that express the B cell follicle homing molecule, CXCR5, are able to accelerate the response, suggesting that the rapidity of the Ab response depends on the ability of CD4 memory T cells to migrate quickly toward B cells.</jats:p>
Journal
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- The Journal of Immunology
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The Journal of Immunology 186 (5), 2889-2896, 2011-03-01
The American Association of Immunologists
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Details 詳細情報について
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- CRID
- 1362262945456674688
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- ISSN
- 15506606
- 00221767
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- Data Source
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- Crossref