Plasma brain natriuretic peptide as a predictor of haemodynamically significant patent ductus arteriosus in preterm infants
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- V.F. PUDDY
- Regional Neonatal Unit, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, U.K.
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- C. AMIRMANSOUR
- Heart Science Centre, Imperial College at the NHLI, Harefield UB9 6JH, U.K.
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- A.F. WILLIAMS
- Regional Neonatal Unit, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, U.K.
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- D.R.J. SINGER
- Heart Science Centre, Imperial College at the NHLI, Harefield UB9 6JH, U.K.
書誌事項
- 公開日
- 2002-06-20
- DOI
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- 10.1042/cs1030075
- 公開者
- Portland Press Ltd.
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説明
<jats:p>Patent ductus arteriosus (PDA) is an important cause of morbidity in extremely preterm infants. As increased plasma brain natriuretic peptide (BNP) is a common feature of adult cardiac disease, we investigated the value of plasma BNP concentration as a predictor of haemodynamically significant PDA in very preterm infants. We studied 18 preterm infants (12 male) of median gestational age 30 weeks (range 24-34), median birth weight 1.46kg (0.54-2.13) and 11 healthy term controls. Plasma BNP levels were measured by double-antibody radioimmunoassay on days 3, 5 and 7 of life, and an echocardiogram was performed on day 7. Six infants of median gestation 26 weeks (26-30), median birth weight 0.92kg (0.54-1.04) had PDA proven by echocardiography on day 7. BNP concentrations (pg/ml) on day 3 were significantly higher in these infants than in the remaining twelve [median 2012 (786-2759) versus 42 (7-704), P<0.001]. In four infants PDA was treated successfully (one surgically, three with non-steroidal anti-inflammatory drugs). Two had haemodynamically insignificant closing ducts. In these infants with therapeutic or spontaneous resolution of a PDA, plasma BNP fell to normal values [median after treatment 9pg/ml (8-27)]. Early measurement of plasma BNP in the first few days of life is a useful method for predicting those preterm infants who may require intervention for PDA.</jats:p>
収録刊行物
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- Clinical Science
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Clinical Science 103 (1), 75-77, 2002-06-20
Portland Press Ltd.
