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- Raquel Sussman
- Marine Biological Laboratory, Woods Hole, MA 02543
書誌事項
- 公開日
- 2007-08-14
- DOI
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- 10.1073/pnas.0706157104
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:p> Damage to the genome is unavoidable in living creatures, because of sunlight exposure as well as environmental chemicals present in food and drinking water. There is a need to monitor and purify the drinking water; therefore, several methods of detection have been developed. A very promising model system for this purpose is the zebrafish ( <jats:italic>Danio rerio</jats:italic> ), which is endowed with special qualities for detecting external as well as internal abnormalities. Grossman and Wei's assay [Grossman L, Wei Q (1995) <jats:italic>Clin Chem</jats:italic> 12:1854–1863], which measures the expression level of a nonreplicating recombinant plasmid DNA containing a UV-damaged luciferase reporter gene, shows that zebrafish can repair chromosomal lesions to a much greater extent than the human population. This vertebrate model is still very promising after possible down-regulation of the DNA repair enzymes. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 104 (33), 13379-13383, 2007-08-14
Proceedings of the National Academy of Sciences
