Antimicrobial Photodynamic Therapy in the Non‐Surgical Treatment of Aggressive Periodontitis: Cytokine Profile in Gingival Crevicular Fluid, Preliminary Results

<jats:p><jats:bold>Background:</jats:bold> Aggressive periodontitis is a specific form of periodontal disease that is characterized by rapid attachment loss and bone destruction. Cytokine profiles are of considerable value when studying disease course during treatment. The aim of this trial was to investigate cytokine levels in the gingival crevicular fluid (GCF) of patients with aggressive periodontitis, after treatment with photodynamic therapy (PDT) or scaling and root planing (SRP), in a split‐mouth design on −7, 0, +1, +7, +30, and +90 days.</jats:p><jats:p><jats:bold>Methods:</jats:bold> Ten patients were randomly treated with PDT using a laser source associated with a photosensitizer or SRP with hand instruments. GCF samples were collected, and the concentrations of tumor necrosis factor‐alpha (TNF‐α) and receptor activator of nuclear factor‐kappa B ligand (RANKL) were determined by enzyme‐linked immunosorbent assays. The data were analyzed using generalized estimating equations to test the associations among treatments, evaluated parameters, and experimental times (α = 0.05).</jats:p><jats:p><jats:bold>Results:</jats:bold> Non‐surgical periodontal treatment with PDT or SRP led to statistically significant reductions in TNF‐α level 30 days following treatment. There were similar levels of TNF‐α and RANKL at the different time points in both groups, with no statistically significant differences.</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> SRP and PDT had similar effects on crevicular TNF‐α and RANKL levels in patients with aggressive periodontitis.</jats:p>