The Antiparasitic Compound Licochalcone A Is a Potent Echinocytogenic Agent That Modifies the Erythrocyte Membrane in the Concentration Range Where Antiplasmodial Activity Is Observed
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- Hanne L. Ziegler
- Department of Medicinal Chemistry
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- Harald S. Hansen
- Department of Pharmacology, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark
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- Dan Stærk
- Department of Medicinal Chemistry
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- Søren Brøgger Christensen
- Department of Medicinal Chemistry
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- Henry Hägerstrand
- Department of Biology, Åbo Akademi University, Åbo/Turku, Finland
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- Jerzy W. Jaroszewski
- Department of Medicinal Chemistry
書誌事項
- 公開日
- 2004-10
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/aac.48.10.4067-4071.2004
- 公開者
- American Society for Microbiology
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説明
<jats:title>ABSTRACT</jats:title> <jats:p> The well-known antiparasitic compound licochalcone A is a potent membrane-active agent that transforms normal erythrocytes into echinocytes in parallel with the inhibition of growth of <jats:italic>Plasmodium falciparum</jats:italic> cultures, the in vitro antiplasmodial effect apparently being an indirect effect on the host cell. In vitro experiments with synchronous cultures demonstrate that inhibition of invasion is the principal mechanism of growth inhibition. The erythrocyte membrane-modifying effect was also transiently observed in vivo in mice after intravenous administration. </jats:p>
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 48 (10), 4067-4071, 2004-10
American Society for Microbiology
