Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells

Ru‐Jia Yu, Yi‐Lun Ying, Rui Gao, Yi‐Tao Long

doi:10.1002/anie.201803229

Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells

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Ru‐Jia Yu

Key Laboratory for Advanced Materials School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 P. R. China
Yi‐Lun Ying

Key Laboratory for Advanced Materials School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 P. R. China
Rui Gao

Key Laboratory for Advanced Materials School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 P. R. China
Yi‐Tao Long

Key Laboratory for Advanced Materials School of Chemistry & Molecular Engineering East China University of Science and Technology Shanghai 200237 P. R. China

書誌事項

公開日: 2018-12-18

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/anie.201803229

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Nanopipettes provide a promising confined space that enables advances in electrochemical, optical, and mass spectrometric measurements at the nanoscale. They have been employed to reveal the hidden population properties and dynamics of single molecules and single particles. Moreover, new detection mechanisms based on nanopipettes have led to detailed information on single cells at high spatial and temporal resolution. In this Minireview, we focus on the fabrication and characterization of nanopipettes, summarize their wide applications for the analysis of single entities, and conclude with an outlook for advanced practical sensing.</jats:p>