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- Jianping Fu
- Massachusetts Institute of Technology Department of Mechanical Engineering, , Cambridge, Massachusetts 02139
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- Pan Mao
- Massachusetts Institute of Technology Department of Mechanical Engineering, , Cambridge, Massachusetts 02139
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- Jongyoon Han
- Massachusetts Institute of Technology Department of Electrical Engineering and Computer Science, Biological Engineering Division, , Cambridge, Massachusetts 02139
抄録
<jats:p>We report here a microfabricated nanofilter array chip that can size-fractionate sodium dodecyl sulfate (SDS)-protein complexes and small DNA molecules based on the Ogston sieving mechanism. Nanofilter arrays with a gap size of 40–180 nm were fabricated and characterized. Complete separation of SDS-protein complexes and small DNA molecules were achieved in several minutes with a separation length of 5 mm. The fabrication strategy for the nanofilter array chip allows further increasing of the nanofilter density and decreasing of the nanofilter gap size, leading, in principle, to even faster separation.</jats:p>
収録刊行物
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- Applied Physics Letters
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Applied Physics Letters 87 (26), 2005-12-22
AIP Publishing