Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells

DOI PDF 被引用文献26件
  • Fumihiko Takeshita
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892
  • Cynthia A Leifer
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892
  • Ihsan Gursel
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892
  • Ken J Ishii
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892
  • Saoko Takeshita
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892
  • Mayda Gursel
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892
  • Dennis M Klinman
    Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration , Bethesda, MD 20892

書誌事項

公開日
2001-10-01
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.167.7.3555
公開者
Oxford University Press (OUP)

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説明

<jats:title>Abstract</jats:title> <jats:p>Unmethylated CpG motifs present in bacterial DNA stimulate a rapid and robust innate immune response. Human cell lines and PBMC that recognize CpG DNA express membrane-bound human Toll-like receptor 9 (hTLR9). Cells that are not responsive to CpG DNA become responsive when transfected with hTLR9. Expression of hTLR9 dramatically increases uptake of CpG (but not control) DNA into endocytic vesicles. Upon cell stimulation, hTLR9 and CpG DNA are found in the same endocytic vesicles. Cells expressing hTLR9 are stimulated by CpG motifs that are active in primates but not rodents, suggesting that evolutionary divergence between TLR9 molecules underlies species-specific differences in the recognition of bacterial DNA. These findings indicate that hTLR9 plays a critical role in the CpG DNA-mediated activation of human cells.</jats:p>

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