Preclinical translation of exosomes derived from mesenchymal stem/stromal cells
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- Fanny M. Elahi
- a Department of Neurology, University of California San Francisco, San Francisco, California
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- D. Gregory Farwell
- b Department of Otolaryngology, University of California Davis, Sacramento, California
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- Jan A. Nolta
- c Institute for Regenerative Cures, University of California Davis, Sacramento, California
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- Johnathon D. Anderson
- b Department of Otolaryngology, University of California Davis, Sacramento, California
書誌事項
- 公開日
- 2019-10-01
- 権利情報
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- http://creativecommons.org/licenses/by-nc/4.0/
- http://creativecommons.org/licenses/by-nc/4.0/
- http://doi.wiley.com/10.1002/tdm_license_1.1
- DOI
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- 10.1002/stem.3061
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal transfer of various macromolecules previously believed to be cell-autonomous in nature, including nonsecretory proteins, various classes of RNA, metabolites, and lipid membrane-associated factors. Exosomes derived from mesenchymal stem/stromal cells (MSCs) appear to be particularly beneficial for enhancing recovery in various models of disease. To date, there have been more than 200 preclinical studies of exosome-based therapies in a number of different animal models. Despite a growing number of studies reporting the therapeutic properties of MSC-derived exosomes, their underlying mechanism of action, pharmacokinetics, and scalable manufacturing remain largely outstanding questions. Here, we review the global trends associated with preclinical development of MSC-derived exosome-based therapies, including immunogenicity, source of exosomes, isolation methods, biodistribution, and disease categories tested to date. Although the in vivo data assessing the therapeutic properties of MSC-exosomes published to date are promising, several outstanding questions remain to be answered that warrant further preclinical investigation.</jats:p> <jats:sec> <jats:title/> </jats:sec>
収録刊行物
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- Stem Cells
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Stem Cells 38 (1), 15-21, 2019-10-01
Oxford University Press (OUP)