Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts
書誌事項
- 公開日
- 2004-10
- 権利情報
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- DOI
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- 10.1016/j.ejphar.2004.08.035
- 公開者
- Elsevier BV
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説明
Given a limited information regarding the difference of the sensitivity of surrogate markers of drug-induced torsades de pointes, including early afterdepolarization, ectopic beats, phase 3 repolarization and dispersion of ventricular repolarization, we simultaneously analyzed them in the halothane-anesthetized canine model (n=5). A non-specific IKr channel blocker sparfloxacin, which has been known to induce torsades de pointes in animals and clinical patients, prolonged the repolarization process in a dose-related and reverse use-dependent manner. No significant change was detected in any of the proarrhythmic markers except for the backward parallel shift of phase 3 repolarization in the cardiac cycle with the QT interval prolongation, which would be the most sensitive marker in predicting the potential arrhythmogenic property of sparfloxacin in the "non-remodeled" normal heart.
収録刊行物
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- European Journal of Pharmacology
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European Journal of Pharmacology 502 (1-2), 117-122, 2004-10
Elsevier BV
