Esophageal tissue engineering: from bench to bedside

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  • Lousineh Arakelian
    Cell Therapy Unit, AP‐HP, Saint‐Louis Hospital Paris Diderot University Paris France
  • Nobuo Kanai
    Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University Tokyo Japan
  • Kulwinder Dua
    Division of Gastroenterology and Hepatology Medical College of Wisconsin Milwaukee Wisconsin
  • Marlène Durand
    University of Bordeaux CHU Bordeaux, CIC1401 Inserm Bordeaux France
  • Pierre Cattan
    Cell Therapy Unit, AP‐HP, Saint‐Louis Hospital Paris Diderot University Paris France
  • Takeshi Ohki
    Department of Surgery, Institute of Gastroenterology Tokyo Women's Medical University Tokyo Japan

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<jats:title>Abstract</jats:title><jats:p>For various esophageal diseases, the search for alternative techniques for tissue repair has led to significant developments in basic and translational research in the field of tissue engineering. Applied to the esophagus, this concept is based on the <jats:italic>in vitro</jats:italic> combination of elements judged necessary for <jats:italic>in vivo</jats:italic> implantation to promote esophageal tissue remodeling. Different methods are currently being explored to develop substitutes using cells, scaffolds, or a combination of both, according to the severity of lesions to be treated. In this review, we discuss recent advances in (1) cell sheet technology for preventing stricture after extended esophageal mucosectomy and (2) full‐thickness circumferential esophageal replacement using tissue‐engineered substitutes.</jats:p>

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