Subretinal electronic chips allow blind patients to read letters and combine them to words
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- Eberhart Zrenner
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Karl Ulrich Bartz-Schmidt
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Heval Benav
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Dorothea Besch
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Anna Bruckmann
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Veit-Peter Gabel
- Eye Clinic, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany
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- Florian Gekeler
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Udo Greppmaier
- Retina Implant AG, Gerhard-Kindler-Str. 8, 72770 Reutlingen, Germany
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- Alex Harscher
- Retina Implant AG, Gerhard-Kindler-Str. 8, 72770 Reutlingen, Germany
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- Steffen Kibbel
- Retina Implant AG, Gerhard-Kindler-Str. 8, 72770 Reutlingen, Germany
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- Johannes Koch
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Akos Kusnyerik
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Tobias Peters
- Steinbeis Transfer Centre Eyetrial at the Centre for Ophthalmology, Schleichstr. 12-16, 72076 Tübingen, Germany
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- Katarina Stingl
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Helmut Sachs
- Klinikum Friedrichstadt, Friedrichstr. 41, 01067 Dresden, Germany
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- Alfred Stett
- NMI Natural and Medical Sciences Institute at the University of Tübingen, Markwiesenstr. 55, 72770 Reutlingen, Germany
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- Peter Szurman
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
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- Barbara Wilhelm
- Steinbeis Transfer Centre Eyetrial at the Centre for Ophthalmology, Schleichstr. 12-16, 72076 Tübingen, Germany
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- Robert Wilke
- Centre for Ophthalmology, University of Tübingen, Schleichstr. 12, 72076 Tübingen, Germany
抄録
<jats:p>A light-sensitive, externally powered microchip was surgically implanted subretinally near the macular region of volunteers blind from hereditary retinal dystrophy. The implant contains an array of 1500 active microphotodiodes (‘chip’), each with its own amplifier and local stimulation electrode. At the implant's tip, another array of 16 wire-connected electrodes allows light-independent direct stimulation and testing of the neuron–electrode interface. Visual scenes are projected naturally through the eye's lens onto the chip under the transparent retina. The chip generates a corresponding pattern of 38 × 40 pixels, each releasing light-intensity-dependent electric stimulation pulses. Subsequently, three previously blind persons could locate bright objects on a dark table, two of whom could discern grating patterns. One of these patients was able to correctly describe and name objects like a fork or knife on a table, geometric patterns, different kinds of fruit and discern shades of grey with only 15 per cent contrast. Without a training period, the regained visual functions enabled him to localize and approach persons in a room freely and to read large letters as complete words after several years of blindness. These results demonstrate for the first time that subretinal micro-electrode arrays with 1500 photodiodes can create detailed meaningful visual perception in previously blind individuals.</jats:p>
収録刊行物
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- Proceedings of the Royal Society B: Biological Sciences
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Proceedings of the Royal Society B: Biological Sciences 278 (1711), 1489-1497, 2010-11-03
The Royal Society
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詳細情報 詳細情報について
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- CRID
- 1362262945996509312
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- ISSN
- 14712954
- 09628452
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- データソース種別
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- Crossref