TFEB Links Autophagy to Lysosomal Biogenesis

  • Carmine Settembre
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131 Naples, Italy.
  • Chiara Di Malta
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131 Naples, Italy.
  • Vinicia Assunta Polito
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131 Naples, Italy.
  • Moises Garcia Arencibia
    Cambridge Institute for Medical Research, Wellcome Trust–Medical Research Council Building, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK.
  • Francesco Vetrini
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Serkan Erdin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Serpil Uckac Erdin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Tuong Huynh
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Diego Medina
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131 Naples, Italy.
  • Pasqualina Colella
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131 Naples, Italy.
  • Marco Sardiello
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • David C. Rubinsztein
    Cambridge Institute for Medical Research, Wellcome Trust–Medical Research Council Building, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK.
  • Andrea Ballabio
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131 Naples, Italy.

説明

<jats:p>Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation.</jats:p>

収録刊行物

  • Science

    Science 332 (6036), 1429-1433, 2011-06-17

    American Association for the Advancement of Science (AAAS)

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