Development of Central Nervous System Metastases in Patients with Advanced Non–Small Cell Lung Cancer and Somatic <i>EGFR</i> Mutations Treated with Gefitinib or Erlotinib
-
- Stephanie Heon
- Authors' Affiliations: 1Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Harvard Medical School; 3Department of Medicine, Massachusetts General Hospital; 4Department of Medicine, Beth Israel Deaconess Medical Center; and 5Brigham and Women's Hospital, Boston, Massachusetts
-
- Beow Y. Yeap
- Authors' Affiliations: 1Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Harvard Medical School; 3Department of Medicine, Massachusetts General Hospital; 4Department of Medicine, Beth Israel Deaconess Medical Center; and 5Brigham and Women's Hospital, Boston, Massachusetts
-
- Gregory J. Britt
- Authors' Affiliations: 1Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Harvard Medical School; 3Department of Medicine, Massachusetts General Hospital; 4Department of Medicine, Beth Israel Deaconess Medical Center; and 5Brigham and Women's Hospital, Boston, Massachusetts
-
- Daniel B. Costa
- Authors' Affiliations: 1Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Harvard Medical School; 3Department of Medicine, Massachusetts General Hospital; 4Department of Medicine, Beth Israel Deaconess Medical Center; and 5Brigham and Women's Hospital, Boston, Massachusetts
-
- Michael S. Rabin
- Authors' Affiliations: 1Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Harvard Medical School; 3Department of Medicine, Massachusetts General Hospital; 4Department of Medicine, Beth Israel Deaconess Medical Center; and 5Brigham and Women's Hospital, Boston, Massachusetts
-
- David M. Jackman
- Authors' Affiliations: 1Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Harvard Medical School; 3Department of Medicine, Massachusetts General Hospital; 4Department of Medicine, Beth Israel Deaconess Medical Center; and 5Brigham and Women's Hospital, Boston, Massachusetts
-
- Bruce E. Johnson
- Authors' Affiliations: 1Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Harvard Medical School; 3Department of Medicine, Massachusetts General Hospital; 4Department of Medicine, Beth Israel Deaconess Medical Center; and 5Brigham and Women's Hospital, Boston, Massachusetts
説明
<jats:title>Abstract</jats:title> <jats:p>Purpose: Gefitinib and erlotinib can penetrate into the central nervous system (CNS) and elicit responses in patients with brain metastases (BM) from non–small cell lung cancer (NSCLC). However, there are incomplete data about their impact on the development and control of CNS metastases.</jats:p> <jats:p>Experimental Design: Patients with stage IIIB/IV NSCLC with somatic EGFR mutations initially treated with gefitinib or erlotinib were identified. The cumulative risk of CNS progression was calculated using death as a competing risk.</jats:p> <jats:p>Results: Of the 100 patients, 19 had BM at the time of diagnosis of advanced NSCLC; 17 of them received CNS therapy before initiating gefitinib or erlotinib. Eighty-four patients progressed after a median potential follow-up of 42.2 months. The median time to progression was 13.1 months. Twenty-eight patients developed CNS progression, 8 of whom had previously treated BM. The 1- and 2-year actuarial risk of CNS progression was 7% and 19%, respectively. Patient age and EGFR mutation genotype were significant predictors of the development of CNS progression. The median overall survival for the entire cohort was 33.1 months.</jats:p> <jats:p>Conclusions: Our data suggest a lower risk of CNS progression in patients with advanced NSCLC and somatic EGFR mutations initially treated with gefitinib or erlotinib than published rates of 40% in historical series of advanced NSCLC patients. Further research is needed to distinguish between the underlying rates of developing CNS metastases between NSCLC with and without EGFR mutations and the impact of gefitinib and erlotinib versus chemotherapy on CNS failure patterns in these patients. Clin Cancer Res; 16(23); 5873–82. ©2010 AACR.</jats:p>
収録刊行物
-
- Clinical Cancer Research
-
Clinical Cancer Research 16 (23), 5873-5882, 2010-12-01
American Association for Cancer Research (AACR)