Recent advances in engineering nonribosomal peptide assembly lines

  • M. Winn
    School of Chemistry and Manchester Institute of Biotechnology
  • J. K. Fyans
    School of Chemistry and Manchester Institute of Biotechnology
  • Y. Zhuo
    School of Chemistry and Manchester Institute of Biotechnology
  • J. Micklefield
    School of Chemistry and Manchester Institute of Biotechnology

書誌事項

公開日
2016
DOI
  • 10.1039/c5np00099h
公開者
Royal Society of Chemistry (RSC)

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説明

<p>This reviews summarises progress towards the engineering of nonribosomal peptide synthetases (NRPS) from the expression of heterologous tailoring enzymes to direct modifications of the assembly lines to produce analogues. New techniques/tools for introducing changes are also examined.</p>

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