Sample size determination for logistic regression on a logit-normal distribution
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- Seongho Kim
- Biostatistics Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
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- Elisabeth Heath
- Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA
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- Lance Heilbrun
- Biostatistics Core, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
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説明
<jats:p> Although the sample size for simple logistic regression can be readily determined using currently available methods, the sample size calculation for multiple logistic regression requires some additional information, such as the coefficient of determination ([Formula: see text]) of a covariate of interest with other covariates, which is often unavailable in practice. The response variable of logistic regression follows a logit-normal distribution which can be generated from a logistic transformation of a normal distribution. Using this property of logistic regression, we propose new methods of determining the sample size for simple and multiple logistic regressions using a normal transformation of outcome measures. Simulation studies and a motivating example show several advantages of the proposed methods over the existing methods: (i) no need for [Formula: see text] for multiple logistic regression, (ii) available interim or group-sequential designs, and (iii) much smaller required sample size. </jats:p>
収録刊行物
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- Statistical Methods in Medical Research
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Statistical Methods in Medical Research 26 (3), 1237-1247, 2015-03-04
SAGE Publications