Content of delusional thoughts in Alzheimer's disease and assessment of content-specific brain dysfunctions with BEHAVE-AD-FW and SPECT
Description
<jats:title>ABSTRACT</jats:title><jats:p><jats:bold>Background:</jats:bold> A consensus on the brain dysfunction(s) underlying the delusions of Alzheimer's Dementia (AD) remains to be achieved. The aim of the present study was to test the hypothesis that content-based categorization of delusional ideas manifests as dysfunction of category-specific brain regions.</jats:p><jats:p><jats:bold>Methods:</jats:bold> Fifty-nine consecutive first-visit AD outpatients underwent Single Photon Emission Computed Tomography (SPECT), Mini-Mental State Examination, and Behavioral Pathology in Alzheimer's Disease Frequency-Weighted Severity scale (BEHAVE-AD-FW) to assess cerebral blood flow (CBF), cognitive function, and delusion, respectively. SPECT images were analyzed by SPM5.</jats:p><jats:p><jats:bold>Results:</jats:bold> CBF decreased at the temporal poles and right inferior temporal gyrus in “delusion of theft,” at the temporal poles in “suspiciousness/paranoia,” at the right parahippocampal gyrus and insula in “abandonment,” and at the right amygdala in “Residence is not home.”</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> Our findings offer a perspective on the discrete categories of the pathological thoughts of AD patients that have previously been lumped together as “delusions.” Dysfunction of the temporal poles may be associated with a socioemotional deterioration that may include pathological suspiciousness. Delusion of theft may be a manifestation of socioemotional deterioration and poor insight. Emotional factors may be essential for delusions of abandonment and “not home.”</jats:p>
Journal
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- International Psychogeriatrics
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International Psychogeriatrics 25 (6), 939-948, 2013-02-22
Cambridge University Press (CUP)
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Details 詳細情報について
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- CRID
- 1362262946279641984
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- ISSN
- 1741203X
- 10416102
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- Data Source
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- Crossref