Glycosylation of the West Nile Virus Envelope Protein Increases In Vivo and In Vitro Viral Multiplication in Birds
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- Ryo Murata
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Yuki Eshita
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Akihiko Maeda
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Junko Maeda
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Saki Akita
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Tomohisa Tanaka
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Kentaro Yoshii
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Hiroaki Kariwa
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Takashi Umemura
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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- Ikuo Takashima
- Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Department of Infectious Disease Control, Faculty of Medicine, Oita University, Oita, Japan; Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine...
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説明
<jats:p>Many West Nile (WN) virus isolates associated with significant outbreaks possess a glycosylation site on the envelope (E) protein. E-protein glycosylated variants of New York (NY) strains of WN virus are more neuroinvasive in mice than the non-glycosylated variants. To determine how E protein glycosylation affects the interactions between WN virus and avian hosts, we inoculated young chicks with NY strains of WN virus containing either glycosylated or non-glycosylated variants of the E protein. The glycosylated variants were more virulent and had higher viremic levels than the non-glycosylated variants. The glycosylation status of the variant did not affect viral multiplication and dissemination in mosquitoes <jats:italic>in vivo</jats:italic>. Glycosylated variants showed more heat-stable propagation than non-glycosylated variants in mammalian (BHK) and avian (QT6) cells but not in mosquito (C6/36) cells. Thus, E-protein glycosylation may be a requirement for efficient transmission of WN virus from avian hosts to mosquito vectors.</jats:p>
収録刊行物
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- The American Society of Tropical Medicine and Hygiene
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The American Society of Tropical Medicine and Hygiene 82 (4), 696-704, 2010-04
American Society of Tropical Medicine and Hygiene