The −174G/C Interleukin-6 Polymorphism Influences Postoperative Interleukin-6 Levels and Postoperative Atrial Fibrillation. Is Atrial Fibrillation an Inflammatory Complication?
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- Mario Gaudino
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Felicita Andreotti
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Roberto Zamparelli
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Augusto Di Castelnuovo
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Giuseppe Nasso
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Francesco Burzotta
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Licia Iacoviello
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Maria Benedetta Donati
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Rocco Schiavello
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Attilio Maseri
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
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- Gianfederico Possati
- From the Department of Cardiac Surgery, Cardiac Anaesthesiology, and Cardiology, Catholic University, Rome, Italy; Angela Valenti Laboratory of Genetic and Environmental Risk Factors for Thrombotic Disease, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy, Research Laboratories. Center for High Technology Research and Education in Biomedical Sciences. Catholic University, Campobasso, Italy.
書誌事項
- 公開日
- 2003-09-09
- DOI
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- 10.1161/01.cir.0000087441.48566.0d
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> It has been suggested that inflammation can have a role in the development of atrial arrhythmias after cardiac surgery and that a genetic predisposition to develop postoperative complications exists. This study was conceived to verify if a potential genetic modulator of the systemic inflammatory reaction to cardiopulmonary bypass (the −174 G/C polymorphism of the promoter of the Interleukin-6 gene) has a role in the pathogenesis of postoperative atrial fibrillation (AF). </jats:p> <jats:p> <jats:bold> <jats:italic>Patients and Results—</jats:italic> </jats:bold> In 110 primary isolated coronary artery bypass patients the −174G/C Interleukin-6 promoter gene variant was determined. Interleukin-6, fibrinogen and C-reactive protein plasma levels were determined preoperatively, 24, 48, and 72 hours after surgery and at discharge. Heart rate and rhythm were continuously monitored for the first 36 to 48 hours; daily 12-lead electrocardiograms were performed thereafter until discharge. GG, CT, and CC genotypes were found in 62, 38, and 10 patients, respectively. Multivariate analysis (which included genotype, age, sex, and classical risk factors for AF) identified the GG genotype as the only independent predictor of postoperative AF. The latter occurred in 33.9% of GG versus 10.4% of non-GG patients (hazard ratio 3.25, 95%CI 1.23 to 8.62). AF patients had higher blood levels of Interleukin-6 and fibrinogen after surgery ( <jats:italic>P</jats:italic> <0.001 for difference between the area under the curve). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusion—</jats:italic> </jats:bold> The −174G/C Interleukin-6 promoter gene variant appears to modulate the inflammatory response to surgery and to influence the development of postoperative AF. These data suggest an inflammatory component of postoperative atrial arrhythmias and a genetic predisposition to this complication. </jats:p>
収録刊行物
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- Circulation
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Circulation 108 (10_suppl_1), II-195-II-, 2003-09-09
Ovid Technologies (Wolters Kluwer Health)