Variable human minisatellite‐like regions in the <i>Mycobacterium tuberculosis</i> genome

Philip Supply, Edith Mazars, Sarah Lesjean, Véronique Vincent, Brigitte Gicquel, Camille Locht

doi:10.1046/j.1365-2958.2000.01905.x

Variable human minisatellite‐like regions in the <i>Mycobacterium tuberculosis</i> genome

DOI Web Site Web Site 被引用文献13件

書誌事項

公開日: 2000-05

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1046/j.1365-2958.2000.01905.x

公開者: Wiley

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説明

<jats:p>Mycobacterial interspersed repetitive units (MIRUs) are 40–100 bp DNA elements often found as tandem repeats and dispersed in intergenic regions of the <jats:italic>Mycobacterium tuberculosis</jats:italic> complex genomes. The <jats:italic>M. tuberculosis</jats:italic> H37Rv chromosome contains 41 MIRU loci. After polymerase chain reaction (PCR) and sequence analyses of these loci in 31 <jats:italic>M. tuberculosis</jats:italic> complex strains, 12 of them were found to display variations in tandem repeat copy numbers and, in most cases, sequence variations between repeat units as well. These features are reminiscent of those of certain human variable minisatellites. Of the 12 variable loci, only one was found to vary among genealogically distant BCG substrains, suggesting that these interspersed bacterial minisatellite‐like structures evolve slowly in mycobacterial populations.</jats:p>