Tandem Synthesis of Amides and Secondary Amines from Esters with Primary Amines under Solvent‐Free Conditions

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<jats:title>Abstract</jats:title><jats:p>An iridium(III)‐catalyzed tandem synthesis of amides and amines from esters under solvent‐free conditions is described. A commercially available iridium(III) complex, [Cp*IrCl<jats:sub>2</jats:sub>]<jats:sub>2</jats:sub>, with sodium acetate showed the best activity for the synthesis of amides and secondary amines. The amide was formed by ester‐amide exchange which generates an alcohol <jats:italic>in situ</jats:italic> which is subsequently transformed to a secondary amine <jats:italic>via</jats:italic> hydrogen autotransfer. This synthetic protocol with high atom economy generates water as the sole by‐product and can afford amides and amines from various esters in a one‐pot reaction, expanding the synthetic versatility of ester transformations.</jats:p><jats:p><jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/gif" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/mcontent.gif"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p>

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