Weak Palindromic Consensus Sequences Are a Common Feature Found at the Integration Target Sites of Many Retroviruses

DOI Web Site 1 Citations
  • Xiaolin Wu
    Laboratory of Molecular Technology
  • Yuan Li
    AIDS Vaccine Program, Scientific Application International Corporation, National Cancer Institute at Frederick, Frederick
  • Bruce Crise
    AIDS Vaccine Program, Scientific Application International Corporation, National Cancer Institute at Frederick, Frederick
  • Shawn M. Burgess
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland
  • David J. Munroe
    Laboratory of Molecular Technology

Description

<jats:title>ABSTRACT</jats:title> <jats:p>Integration into the host genome is one of the hallmarks of the retroviral life cycle and is catalyzed by virus-encoded integrases. While integrase has strict sequence requirements for the viral DNA ends, target site sequences have been shown to be very diverse. We carefully examined a large number of integration target site sequences from several retroviruses, including human immunodeficiency virus type 1, simian immunodeficiency virus, murine leukemia virus, and avian sarcoma-leukosis virus, and found that a statistical palindromic consensus, centered on the virus-specific duplicated target site sequence, was a common feature at integration target sites for these retroviruses.</jats:p>

Journal

  • Journal of Virology

    Journal of Virology 79 (8), 5211-5214, 2005-04-15

    American Society for Microbiology

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