Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations
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- Thomas Lehrnbecher
- From the Immunocompromised Host Section, Pediatric Oncology Branch, the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Laboratory of Genetics, National Cancer Institute, and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
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- Charles B. Foster
- From the Immunocompromised Host Section, Pediatric Oncology Branch, the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Laboratory of Genetics, National Cancer Institute, and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
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- Shaoxian Zhu
- From the Immunocompromised Host Section, Pediatric Oncology Branch, the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Laboratory of Genetics, National Cancer Institute, and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
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- Susan F. Leitman
- From the Immunocompromised Host Section, Pediatric Oncology Branch, the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Laboratory of Genetics, National Cancer Institute, and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
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- Lynn R. Goldin
- From the Immunocompromised Host Section, Pediatric Oncology Branch, the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Laboratory of Genetics, National Cancer Institute, and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
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- Konrad Huppi
- From the Immunocompromised Host Section, Pediatric Oncology Branch, the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Laboratory of Genetics, National Cancer Institute, and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
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- Stephen J. Chanock
- From the Immunocompromised Host Section, Pediatric Oncology Branch, the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Laboratory of Genetics, National Cancer Institute, and the Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
説明
<jats:title>Abstract</jats:title><jats:p>Fcγ-receptors (FcγR) provide a critical link between humoral and cellular immunity. The genes of the low-affinity receptors for IgG and their isoforms, namely, FcγRIIa, FcγRIIb, FcγRIIIa, FcγRIIIb, and SH-FcγRIIIb, are located in close proximity on chromosome 1q22. Variant alleles may differ in biologic activity and a number of studies have reported the frequencies of variant FcγR alleles in both disease and control populations. No large study has evaluated the possibility of a nonrandom distribution of variant genotypes. We analyzed 395 normal individuals (172 African Americans [AA] and 223 Caucasians [CA]) at the following loci: FcγRIIa, FcγRIIIa, and FcγRIIIb, including the SH-FcγRIIIb. The genotypic distributions of FcγRIIa, FcγRIIIa, and FcγRIIIb conform to the Hardy-Weinberg law in each group. There was no strong evidence that combinations of 2-locus genotypes of the 3 loci deviated from random distributions in these healthy control populations. The distribution of SH-FcγRIIIb is underrepresented in CA compared with AA (P < .0001) controls. A previously reported variant FcγRIIb was not detected in 70 normal individuals, indicating that this allele, if it exists, is very rare (<1%). In conclusion, we present data that should serve as the foundation for the interpretation of association studies involving multiple variant alleles of the low-affinity FcγR.</jats:p>
収録刊行物
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- Blood
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Blood 94 (12), 4220-4232, 1999-12-15
American Society of Hematology
