What Can Progeroid Syndromes Tell Us About Human Aging?

DOI Web Site 被引用文献3件
  • David Kipling
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
  • Terence Davis
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
  • Elizabeth L. Ostler
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
  • Richard G. A. Faragher
    Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

書誌事項

公開日
2004-09-03
DOI
  • 10.1126/science.1102587
公開者
American Association for the Advancement of Science (AAAS)

この論文をさがす

説明

<jats:p>Human genetic diseases that resemble accelerated aging provide useful models for gerontologists. They combine known single-gene mutations with deficits in selected tissues that are reminiscent of changes seen during normal aging. Here, we describe recent progress toward linking molecular and cellular changes with the phenotype seen in two of these disorders. One in particular, Werner syndrome, provides evidence to support the hypothesis that the senescence of somatic cells may be a causal agent of normal aging.</jats:p>

収録刊行物

  • Science

    Science 305 (5689), 1426-1431, 2004-09-03

    American Association for the Advancement of Science (AAAS)

被引用文献 (3)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ