Two New 11(15→1)Abeotaxanes with a 2,20-Epoxy Ring from the Needles of Taxus canadensis

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  • Man-Li Zhang
    School of Pharmaceutical Sciences and College of Basic Medical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China
  • Jing Zhang
    The Third Affi liated Hospital of Hebei Medical University, 050000, Shijiazhuang, Hebei Province, P. R. China
  • Mei Dong
    School of Pharmaceutical Sciences and College of Basic Medical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China
  • Shu-Hua Feng
    Drug Control Institute of Hebei Province, Fuqing Dajie, 050012, Shijiazhuang, Hebei Province, P. R. China
  • Chang-Hong Huo
    School of Pharmaceutical Sciences and College of Basic Medical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China
  • Françoise Sauriol
    Department of Chemistry, Queen’s University, Kingston, Ontario K7L 3N6, Canada
  • Qing-Wen Shi
    School of Pharmaceutical Sciences and College of Basic Medical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China
  • Yu-Cheng Gu
    Syngenta Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
  • Hiromasa Kiyota
    Department of Bioscience and Biotechnology for Future Bioindustry, Graduate School of Agricultural Science, Tohoku University, 1 – 1 Tsutsumidori-Amamiya, Aoba-ku, Sendai, 981 – 8555, Japan
  • Bin Cong
    School of Pharmaceutical Sciences and College of Basic Medical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China

抄録

<jats:title>1</jats:title> <jats:p>Two 11(15→1)abeotaxanes having a tetrahydrofuran ring along the carbon atoms C-2, C-3, C-4, C-20 were identified for the first time from the needles of the Canadian yew, Taxus canadensis. The compounds could be identified as 4α,10β,13α-triacetoxy-15-benzoyloxy-2α,20β- epoxy-11(15→1)abeotax-11-ene-5α,7β,9α-triol () and 4α,7β,9α,10β,15-pentaacetoxy-2α,20β- epoxy-11(15→1)abeotax-11-ene-5α,13α-diol (<jats:bold>2</jats:bold>) on the basis of 1D-, 2D-NMR evidence and high-resolution FABMS analysis. Compound <jats:bold>1 </jats:bold>showed weak growth inhibitory activities against T-98 and MM1-CB cells in vitro.</jats:p>

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