Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the <scp>MASK</scp> study
-
- J. Bousquet
- MACVIA‐France Contre les MAladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site Montpellier France
-
- P. Devillier
- Laboratoire de Pharmacologie Respiratoire UPRES EA220 Pôle des Maladies Respiratoires Hôpital Foch Suresnes Université Versailles Saint‐Quentin Suresnes France
-
- J. M. Anto
- ISGloBAL Centre for Research in Environmental Epidemiology (CREAL) Barcelona Spain
-
- M. Bewick
- iQ4U Consultants Ltd London UK
-
- T. Haahtela
- Skin and Allergy Hospital Helsinki University Hospital Helsinki Finland
-
- S. Arnavielhe
- Kyomed Montpellier France
-
- A. Bedbrook
- MACVIA‐France Contre les MAladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site Montpellier France
-
- R. Murray
- MedScript Ltd Dundalk Ireland
-
- M. van Eerd
- Peercode DV Gerdermalsen The Netherlands
-
- J. A. Fonseca
- Faculdade de Medicina Center for Health Technology and Services Research‐ CINTESIS MEDIDA, Lda Universidade do Porto Porto Portugal
-
- M. Morais Almeida
- Allergy and Clinical Immunology Department Hospital CUF‐Descobertas Lisboa Portugal
-
- A. Todo Bom
- Imunoalergologia Faculty of Medicine Centro Hospitalar Universitário de Coimbra University of Coimbra Coimbra Portugal
-
- E. Menditto
- CIRFF Center of Pharmacoeconomics University of Naples Federico II Naples Italy
-
- G. Passalacqua
- Allergy and Respiratory Diseases Ospedale Policlinico San Martino University of Genoa Genoa Italy
-
- C. Stellato
- Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana” University of Salerno Salerno Italy
-
- M. Triggiani
- Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana” University of Salerno Salerno Italy
-
- M. T. Ventura
- Unit of Geriatric Immunoallergology University of Bari Medical School Bari Italy
-
- G. Vezzani
- Pulmonary Unit Department of Medical Specialties Arcispedale SMaria Nuova/IRCCS AUSL di Reggio Emilia Reggio Emilia Italy
-
- I. Annesi‐Maesano
- Epidemiology of Allergic and Respiratory Diseases Department Institute Pierre Louis of Epidemiology and Public Health INSERM Medical School Saint Antoine UPMC Sorbonne Universités Paris France
-
- R. Bourret
- Centre Hospitalier Valenciennes France
-
- I. Bosse
- Allergist La Rochelle France
-
- D. Caimmi
- CHRU de Montpellier UMR‐S 1136 IPLESP Equipe EPAR UPMC Paris 06 Sorbonne Universités Paris France
-
- C. Cartier
- ASA ‐ Advanced Solutions Accelerator Clapiers France
-
- P. Demoly
- CHRU de Montpellier UMR‐S 1136 IPLESP Equipe EPAR UPMC Paris 06 Sorbonne Universités Paris France
-
- J. Just
- Allergology Department Centre de l'Asthme et des Allergies Hôpital d'Enfants Armand‐Trousseau (APHP) Paris France
-
- F. Portejoie
- MACVIA‐France Contre les MAladies Chroniques pour un VIeillissement Actif en France European Innovation Partnership on Active and Healthy Ageing Reference Site Montpellier France
-
- V. Siroux
- INSERM IAB, U 1209 Team of Environmental Epidemiology applied to Reproduction and Respiratory Health Université Grenoble Alpes Université Joseph Fourier Grenoble France
-
- F. Viart
- ASA ‐ Advanced Solutions Accelerator Clapiers France
-
- K. C. Bergmann
- Department of Dermatology and Allergy Comprehensive Allergy‐Centre‐Charité Charité ‐ Universitätsmedizin Berlin Berlin Germany
-
- T. Keil
- Institute of Social Medicine, Epidemiology and Health Economics Charité ‐ Universitätsmedizin Berlin Berlin Germany
-
- L. Klimek
- Center for Rhinology and Allergology Wiesbaden Germany
-
- R. Mösges
- CRI‐Clinical Research International‐Ltd Hamburg Germany
-
- O. Pfaar
- Center for Rhinology and Allergology Wiesbaden Germany
-
- S. Shamai
- CRI‐Clinical Research International‐Ltd Hamburg Germany
-
- T. Zuberbier
- Department of Dermatology and Allergy Comprehensive Allergy‐Centre‐Charité Charité ‐ Universitätsmedizin Berlin Berlin Germany
-
- J. Mullol
- Rhinology Unit & Smell Clínic ENT Department Hospital Clinic University of Barcelona Barcelona Spain
-
- A. Valero
- Rhinology Unit & Smell Clínic ENT Department Hospital Clinic University of Barcelona Barcelona Spain
-
- O. Spranger
- Global Allergy and Asthma Platform GAAPP Vienna Austria
-
- P. V. Tomazic
- Department of ENT Medical University of Graz Graz Austria
-
- M. L. Kowalski
- Department of Immunology, Rheumatology and Allergy HARC Medical University of Lodz Lodz Poland
-
- P. Kuna
- Division of Internal Medicine, Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland
-
- M. Kupczyk
- Division of Internal Medicine, Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland
-
- F. Raciborski
- Department of Prevention of Envinronmental Hazards and Allergology Medical University of Warsaw Warsaw Poland
-
- B. Samolinski
- Department of Prevention of Envinronmental Hazards and Allergology Medical University of Warsaw Warsaw Poland
-
- S. K. Toppila‐Salmi
- Skin and Allergy Hospital Helsinki University Hospital Helsinki Finland
-
- E. Valovirta
- Department of Lung Diseases and Clinical Immunology University of Turku Turku Finland
-
- A. A. Cruz
- ProAR – Nucleo de Excelencia em Asma Federal University of Bahia Salvador Brasil
-
- F. Sarquis‐Serpa
- Asthma Reference Center Escola Superior de Ciencias da Santa Casa de Misericordia de Vitoria Esperito Santo Brazil
-
- J. da Silva
- Nucleo de Alergia Hospital Universitario Polydoro Ernani de Sao Thiago Federal University of Santa Catarina (HU‐UFSC) Florioanopolis Brazil
-
- R. Stelmach
- Pulmonary Division Heart Institute (InCor) Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil
-
- D. Larenas‐Linnemann
- Center of Excellence in Asthma and Allergy Hospital Médica Sur México City Mexico
-
- M. Rodriguez Gonzalez
- Pediatric Allergy and Clinical Immunology Hospital Angeles Pedregal Mexico City Mexico
-
- M. T. Burguete Cabañas
- Centro Médico Zambrano Hellion Monterrey Mexico
-
- V. Kvedariene
- Departement of Pathology, Forensic Medicine and Pharmacology Faculty of Medicine Clinic of Infecious, Chest Diseases, Dermatology and Allergology Institute of Biomedical Sciences Vilnius University Vilnius Lithuania
-
- A. Valiulis
- Department of Public Health Clinic of Children's Diseases Institute of Health Sciences Vilnius University Institute of Clinical Medicine Vilnius Lithuania
-
- N. H. Chavannes
- Department of Public Health and Primary Care Leiden University Medical Center Leiden The Netherlands
-
- W. J. Fokkens
- Department of Otorhinolaryngology Academic Medical Centre Amsterdam The Netherlands
-
- D. Ryan
- Allergy and Respiratory Research Group Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK
-
- A. Sheikh
- Asthma UK Centre for Applied Research Centre of Medical Informatics Usher Institute of Population Health Sciences and Informatics The University of Edinburgh Edinburgh UK
-
- C. Bachert
- ENT Department Upper Airways Research Laboratory Ghent University Hospital Ghent Belgium
-
- P. W. Hellings
- Euforea Brussels Belgium
-
- O. VandenPlas
- Department of Chest Medicine Centre Hospitalier Universitaire UCL Namur Université Catholique de Louvain Yvoir Belgium
-
- N. Ballardini
- Centre for Clinical Research Sörmland Uppsala University Eskilstuna Sweden
-
- I. Kull
- Allergy and Respiratory Research Group Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK
-
- E. Melén
- Sachs’ Children and Youth Hospital Södersjukhuset Stockholm Sweden
-
- M. Westman
- Department of Medicine Solna Immunology and Allergy Unit Karolinska Institutet Stockholm Sweden
-
- M. Wickman
- Centre for Clinical Research Sörmland Uppsala University Eskilstuna Sweden
-
- C. Bindslev‐Jensen
- Department of Dermatology and Allergy Centre Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark
-
- E. Eller
- Department of Dermatology and Allergy Centre Odense Research Center for Anaphylaxis (ORCA) Odense University Hospital Odense Denmark
-
- S. Bosnic‐Anticevich
- Woolcock Institute of Medical Research Sydney Local Health District University of Sydney Glebe NSW Australia
-
- R. E. O'Hehir
- Department of Allergy, Immunology and Respiratory Medicine Alfred Hospital and Central Clinical School Monash University Melbourne Vic. Australia
-
- I. Agache
- Transylvania University Brasov Romania
-
- T. Bieber
- Department of Dermatology and Allergy Rheinische Friedrich‐Wilhelms‐University Bonn Bonn Germany
-
- T. Casale
- Division of Allergy/Immunology University of South Florida Tampa FL USA
-
- B. Gemicioğlu
- Department of Pulmonary Diseases Cerrahpasa Faculty of Medicine Istanbul University Istanbul Turkey
-
- J. C. Ivancevich
- Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina
-
- G. De Vries
- Peercode DV Gerdermalsen The Netherlands
-
- M. Sorensen
- Department of Paediatric and Adolescent Medicine University Hospital of North Norway Tromsø Norway
-
- A. Yorgancioglu
- Department of Pulmonology Celal Bayar University Manisa Turkey
-
- D. Laune
- Kyomed Montpellier France
抄録
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the <jats:italic>Allergy Diary</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We undertook a 1‐year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis‐driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High—Asthma Low pattern. There were 1.7% days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In a novel approach examining daily symptoms with mobile technology, we found considerable intra‐individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.</jats:p></jats:sec>
収録刊行物
-
- Allergy
-
Allergy 73 (8), 1622-1631, 2018-04-24
Wiley