SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions

DOI Web Site 1 Citations
  • Mohammed Uddin
    College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
  • Farah Mustafa
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
  • Tahir A. Rizvi
    Department of Microbiology & Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
  • Tom Loney
    College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
  • Hanan Al Suwaidi
    College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
  • Ahmed H. Hassan Al-Marzouqi
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
  • Afaf Kamal Eldin
    Department of Food, Nutrition and Health, United Arab Emirates University, Al Ain, UAE
  • Nabeel Alsabeeha
    Ministry of Health and Prevention, Dubai, UAE
  • Thomas E. Adrian
    College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
  • Cesare Stefanini
    Department of Biomedical Engineering, Healthcare Engineering Innovation Center (HEIC), Khalifa University, Abu Dhabi, UAE
  • Norbert Nowotny
    College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
  • Alawi Alsheikh-Ali
    College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE
  • Abiola C. Senok
    College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE

Description

<jats:p>The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respiratory distress, and fatality. To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development. Therefore, this review provides a comprehensive overview of COVID-19 epidemiology, genomic etiology, findings from recent transcriptomic map analysis, viral-human protein interactions, molecular diagnostics, and the current status of vaccine and novel therapeutic intervention development. Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment.</jats:p>

Journal

  • Viruses

    Viruses 12 (5), 526-, 2020-05-10

    MDPI AG

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