Important roles played by TGF‐β in hepatitis B infection
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- Masoud Karimi‐Googheri
- Department of Immunology Kerman University of Medical Sciences Kerman Iran
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- Hamid Daneshvar
- Department of Immunology Kerman University of Medical Sciences Kerman Iran
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- Reza Nosratabadi
- Immunology of Infectious Diseases Research Center Rafsanjan University of Medical Sciences Rafsanjan Iran
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- Mohammad Zare‐Bidaki
- Immunology of Infectious Diseases Research Center Rafsanjan University of Medical Sciences Rafsanjan Iran
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- Gholamhossein Hassanshahi
- Molecular Medicine Research Center Rafsanjan University of Medical Sciences Rafsanjan Iran
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- Maryam Ebrahim
- Immunology of Infectious Diseases Research Center Rafsanjan University of Medical Sciences Rafsanjan Iran
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- Mohammad Kazemi Arababadi
- Immunology of Infectious Diseases Research Center Rafsanjan University of Medical Sciences Rafsanjan Iran
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- Derek Kennedy
- School of Biomolecular and Physical Science Eskitis Institute for Drug Discovery Griffith University Nathan Queensland Australia
Description
<jats:title>Abstract</jats:title><jats:sec><jats:label /><jats:p>Hepatitis B virus (HBV) which includes, fulminant, acute, chronic, asymptomatic, and occult HBV infection is the most prevalent virus that leads to human liver diseases. Chronic, asymptomatic, and occult infection can induce further sever diseases such as hepatocellular carcinoma (HCC) and cirrhosis of the liver. The underlying mechanisms that allow progression of the prolonged forms of the infection and subsequent HCC or cirrhosis of the liver are yet to be clarified. However, many researchers have suggested that immunological and genetic parameters may play important roles in the etiology of hepatitis B. Transforming growth factor beta (TGF‐β) is an important cytokine with dual regulatory functions in the immune system and in the responses against viral infections. However, the pathways and mechanisms controlling these are not fully understood. The crucial roles of TGF‐β in the development of Th17 and T regulatory lymphocytes, the main cell types involved in autoimmunity and destructive immune related diseases, have been documented and this provides insights into TGF‐β function during hepatitis infection and subsequent HCC and cirrhosis of the liver. Recent findings also confirm that TGF‐β directly alters hepatocyte function during hepatitis B, hence, the aim of this review is to address the current data regarding the association and status of TGF‐β with hepatitis B infection and its related disorders including HCC and cirrhosis of the liver. <jats:bold><jats:italic>J. Med. Virol. 86:102–108, 2014</jats:italic>.</jats:bold> © 2013 Wiley Periodicals, Inc.</jats:p></jats:sec>
Journal
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- Journal of Medical Virology
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Journal of Medical Virology 86 (1), 102-108, 2013-09-05
Wiley
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Details 詳細情報について
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- CRID
- 1362544418629582464
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- ISSN
- 10969071
- 01466615
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- Data Source
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- Crossref