More Than 200 Genes Required for Methane Formation from H<sub>2</sub>and CO<sub>2</sub>and Energy Conservation Are Present in<i>Methanothermobacter marburgensis</i>and<i>Methanothermobacter thermautotrophicus</i>
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- Anne-Kristin Kaster
- Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany
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- Meike Goenrich
- Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany
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- Henning Seedorf
- Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis MO 63108, USA
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- Heiko Liesegang
- Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University, 37077 Göttingen, Germany
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- Antje Wollherr
- Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University, 37077 Göttingen, Germany
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- Gerhard Gottschalk
- Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University, 37077 Göttingen, Germany
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- Rudolf K. Thauer
- Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany
説明
<jats:p>The hydrogenotrophic methanogens<jats:italic>Methanothermobacter marburgensis</jats:italic>and<jats:italic>Methanothermobacter thermautotrophicus</jats:italic>can easily be mass cultured. They have therefore been used almost exclusively to study the biochemistry of methanogenesis from H<jats:sub>2</jats:sub>and CO<jats:sub>2</jats:sub>, and the genomes of these two model organisms have been sequenced. The close relationship of the two organisms is reflected in their genomic architecture and coding potential. Within the 1,607 protein coding sequences (CDS) in common, we identified approximately 200 CDS required for the synthesis of the enzymes, coenzymes, and prosthetic groups involved in CO<jats:sub>2</jats:sub>reduction to methane and in coupling this process with the phosphorylation of ADP. Approximately 20 additional genes, such as those for the biosynthesis of F<jats:sub>430</jats:sub>and methanofuran and for the posttranslational modifications of the two methyl-coenzyme M reductases, remain to be identified.</jats:p>
収録刊行物
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- Archaea
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Archaea 2011 1-23, 2011
Hindawi Limited
