Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

DOI Web Site PubMed 被引用文献62件
  • Yong Gu
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
  • Keisuke Kuida
    K. Kuida, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
  • Hiroko Tsutsui
    H. Tsutsui, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Japan.
  • George Ku
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
  • Kathy Hsiao
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
  • Mark A. Fleming
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
  • Nobuki Hayashi
    H. Tsutsui, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Japan.
  • Kazuya Higashino
    H. Tsutsui, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Japan.
  • Haruki Okamura
    H. Tsutsui, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Japan.
  • Kenji Nakanishi
    H. Tsutsui, N. Hayashi, K. Higashino, H. Okamura, K. Nakanishi, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Japan.
  • Masashi Kurimoto
    M. Kurimoto and T. Tanimoto, Fujisaki Institute, Hayashibara Biochemical Laboratories, Hayashibara Company Inc., Okayama, Japan.
  • Tadao Tanimoto
    M. Kurimoto and T. Tanimoto, Fujisaki Institute, Hayashibara Biochemical Laboratories, Hayashibara Company Inc., Okayama, Japan.
  • Richard A. Flavell
    R. A. Flavell, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Vicki Sato
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
  • Matthew W. Harding
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
  • David J. Livingston
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.
  • Michael S.-S. Su
    Y. Gu, G. Ku, K. Hsiao, M. A. Fleming, V. Sato, M. W. Harding, D. J. Livingston, M. S.-S. Su, Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA.

書誌事項

公開日
1997-01-10
DOI
  • 10.1126/science.275.5297.206
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-γ inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE <jats:sup>−/−</jats:sup> ) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-γ and IGIF were diminished in the sera of ICE <jats:sup>−/−</jats:sup> mice exposed to <jats:italic>Propionibacterium acnes</jats:italic> and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE <jats:sup>−/−</jats:sup> mice may account for their protection from septic shock. </jats:p>

収録刊行物

  • Science

    Science 275 (5297), 206-209, 1997-01-10

    American Association for the Advancement of Science (AAAS)

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