Suppression of CD4+ T Lymphocyte Effector Functions by CD4+CD25+ Cells In Vivo

DOI PDF 被引用文献1件
  • Bruno Martin
    Institut National de la Santé et de la Recherche Médicale Unité 561, Hôpital Saint Vincent de Paul , Paris ,
  • Alice Banz
    Institut National de la Santé et de la Recherche Médicale Unité 345, Institut Necker, Université René Descartes , Paris ,
  • Boris Bienvenu
    Institut National de la Santé et de la Recherche Médicale Unité 561, Hôpital Saint Vincent de Paul , Paris ,
  • Corinne Cordier
    Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche 94, Hôpital Necker , Paris ,
  • Nicole Dautigny
    Institut National de la Santé et de la Recherche Médicale Unité 345, Institut Necker, Université René Descartes , Paris ,
  • Chantal Bécourt
    Institut National de la Santé et de la Recherche Médicale Unité 561, Hôpital Saint Vincent de Paul , Paris ,
  • Bruno Lucas
    Institut National de la Santé et de la Recherche Médicale Unité 561, Hôpital Saint Vincent de Paul , Paris ,

書誌事項

公開日
2004-03
権利情報
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.4049/jimmunol.172.6.3391
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>CD4+CD25+ regulatory T cells have been extensively studied during the last decade, but how these cells exert their regulatory function on pathogenic effector T cells remains to be elucidated. Naive CD4+ T cells transferred into T cell-deficient mice strongly expand and rapidly induce inflammatory bowel disease (IBD). Onset of this inflammatory disorder depends on IFN-γ production by expanding CD4+ T cells. Coinjection of CD4+CD25+ regulatory T cells protects recipient mice from IBD. In this study, we show that CD4+CD25+ regulatory T cells do not affect the initial activation/proliferation of injected naive T cells as well as their differentiation into Th1 effectors. Moreover, naive T cells injected together with CD4+CD25+ regulatory T cells into lymphopenic hosts are still able to respond to stimuli in vitro when regulatory T cells are removed. In these conditions, they produce as much IFN-γ as before injection or when injected alone. Finally, when purified, they are able to induce IBD upon reinjection into lymphopenic hosts. Thus, prevention of IBD by CD4+CD25+ regulatory T cells is not due to deletion of pathogenic T cells, induction of a non reactive state (anergy) among pathogenic effector T cells, or preferential induction of Th2 effectors rather than Th1 effectors; rather, it results from suppression of T lymphocyte effector functions, leading to regulated responses to self.</jats:p>

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