Identification of Novel Genes Regulated by IL-12, IL-4, or TGF-β during the Early Polarization of CD4+ Lymphocytes
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- Riikka Lund
- Turku Centre for Biotechnology, Turku University and Åbo Akademi, Turku University , Turku ,
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- Tero Aittokallio
- Turku Centre for Computer Science, Turku University , Turku ,
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- Olli Nevalainen
- Turku Centre for Computer Science, Turku University , Turku ,
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- Riitta Lahesmaa
- Turku Centre for Biotechnology, Turku University and Åbo Akademi, Turku University , Turku ,
書誌事項
- 公開日
- 2003-11
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.4049/jimmunol.171.10.5328
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to certain immune-mediated diseases. Thus, it is important to understand how Th1 and Th2 cells are generated. To clarify the mechanisms as to how IL-12 and IL-4 induce Th1 and Th2 differentiation and how TGF-β can inhibit this process, we have used oligonucleotide arrays to examine the early polarization of Th1 and Th2 cells in the presence and absence of TGF-β. In addition to genes previously implicated in the process, we have identified 20 genes with various known and unknown functions not previously associated with Th1/2 polarization. We have also further determined which genes are targets of IL-12, IL-4, and TGF-β regulation in the cells induced to polarize to Th1 and Th2 directions. Interestingly, a subset of the genes was coregulated by IL-12 or IL-4 and TGF-β. Among these genes are candidates that may modulate the balance between Th1 and Th2 responses.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 171 (10), 5328-5336, 2003-11
Oxford University Press (OUP)