Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes
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- Rong Hai
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Florian Krammer
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Gene S. Tan
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Natalie Pica
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Dirk Eggink
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Jad Maamary
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Irina Margine
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Randy A. Albrecht
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
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- Peter Palese
- Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
書誌事項
- 公開日
- 2012-05-15
- 権利情報
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/jvi.00137-12
- 公開者
- American Society for Microbiology
この論文をさがす
説明
<jats:title>ABSTRACT</jats:title> <jats:p>The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding and a stalk domain at the membrane-proximal region. We generated functional influenza viruses expressing chimeric hemagglutinins encompassing a variety of globular head and stalk combinations, not only from different hemagglutinin subtypes but also from different hemagglutinin phylogenetic groups. These chimeric recombinant viruses possess growth properties similar to those of wild-type influenza viruses and can be used as reagents to measure domain-specific antibodies in virological and immunological assays.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 86 (10), 5774-5781, 2012-05-15
American Society for Microbiology