Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

DOI Web Site PubMed 被引用文献60件
  • Mutsuki Amano
    M. Amano, K. Chihara, Y. Fukata, N. Nakamura, K. Kaibuchi, Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan.
  • Kazuyasu Chihara
    M. Amano, K. Chihara, Y. Fukata, N. Nakamura, K. Kaibuchi, Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan.
  • Kazushi Kimura
    K. Kimura, Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan, and Second Department of Anatomy, Kyoto University Faculty of Medicine, Kyoto 606, Japan.
  • Yuko Fukata
    M. Amano, K. Chihara, Y. Fukata, N. Nakamura, K. Kaibuchi, Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan.
  • Nao Nakamura
    M. Amano, K. Chihara, Y. Fukata, N. Nakamura, K. Kaibuchi, Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan.
  • Yoshiharu Matsuura
    Y. Matsuura, Department of Virology II, National Institute of Health, Tokyo 162, Japan.
  • Kozo Kaibuchi
    M. Amano, K. Chihara, Y. Fukata, N. Nakamura, K. Kaibuchi, Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-01, Japan.

書誌事項

公開日
1997-02-28
DOI
  • 10.1126/science.275.5304.1308
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>The small guanosine triphosphatase (GTPase) Rho is implicated in the formation of stress fibers and focal adhesions in fibroblasts stimulated by extracellular signals such as lysophosphatidic acid (LPA). Rho-kinase is activated by Rho and may mediate some biological effects of Rho. Microinjection of the catalytic domain of Rho-kinase into serum-starved Swiss 3T3 cells induced the formation of stress fibers and focal adhesions, whereas microinjection of the inactive catalytic domain, the Rho-binding domain, or the pleckstrin-homology domain inhibited the LPA-induced formation of stress fibers and focal adhesions. Thus, Rho-kinase appears to mediate signals from Rho and to induce the formation of stress fibers and focal adhesions.</jats:p>

収録刊行物

  • Science

    Science 275 (5304), 1308-1311, 1997-02-28

    American Association for the Advancement of Science (AAAS)

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