Molecular Characterization of a Shiga Toxigenic <i>Escherichia coli</i> O113:H21 Strain Lacking <i>eae</i> Responsible for a Cluster of Cases of Hemolytic-Uremic Syndrome

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  • Adrienne W. Paton
    <!--label omitted: 1-->Molecular Microbiology Unit, Women’s and Children’s Hospital, North Adelaide, S.A. 5006,1 and
  • Matthew C. Woodrow
    <!--label omitted: 1-->Molecular Microbiology Unit, Women’s and Children’s Hospital, North Adelaide, S.A. 5006,1 and
  • Robyn M. Doyle
    <!--label omitted: 2-->Division of Clinical Microbiology, Institute of Medical and Veterinary Science, Adelaide, S.A. 5000,2 Australia
  • Janice A. Lanser
    <!--label omitted: 2-->Division of Clinical Microbiology, Institute of Medical and Veterinary Science, Adelaide, S.A. 5000,2 Australia
  • James C. Paton
    <!--label omitted: 1-->Molecular Microbiology Unit, Women’s and Children’s Hospital, North Adelaide, S.A. 5006,1 and

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<jats:title>ABSTRACT</jats:title> <jats:p> Shiga toxigenic <jats:italic>Escherichia coli</jats:italic> (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear to have greater virulence for humans. STEC strains carrying <jats:italic>eae</jats:italic> and belonging to serogroup O157 or O111 have been responsible for the vast majority of outbreaks of STEC disease reported to date. Here we describe a STEC O113:H21 strain lacking <jats:italic>eae</jats:italic> that was responsible for a cluster of three cases of hemolytic-uremic syndrome. This strain produces a single Stx2-related toxin and adheres efficiently to Henle 407 cells. </jats:p>

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