Mutational specificity of the umuC mediated mutagenesis in Eschericha coli

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A current concept of UV mutagenesis in E. coli is one of the inducible functions triggered by the arrest of DNA synthesis following exposure to various mutagens [18, 29]. We have previously identified the gene umuC which specifically controls the inducible mutagenic function [9]. The function, however, does not seem essential for the cell, since many bacterial genera have been known to lack this function [27]. Besides, a gene (mue) or genetic elements which confer the umuC genelike function have been found on several bacterial plasmids [18]. This may imply a transposable element associated origin of those genetic materials.

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  • Biochimie

    Biochimie 64 (8-9), 731-733, 1982-09

    Elsevier BV

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