Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis

Description

<jats:title>SUMMARY</jats:title><jats:p>Immune responses to respiratory viruses like SARS-CoV-2 originate and function in the lung, yet assessments of human immunity are often limited to blood. Here, we conducted longitudinal, high-dimensional profiling of paired airway and blood samples from patients with severe COVID-19, revealing immune processes in the respiratory tract linked to disease pathogenesis. Survival from severe disease was associated with increased CD4<jats:sup>+</jats:sup>T cells and decreased monocyte/macrophage frequencies in the airway, but not in blood. Airway T cells and macrophages exhibited tissue-resident phenotypes and activation signatures, including high level expression and secretion of monocyte chemoattractants CCL2 and CCL3 by airway macrophages. By contrast, monocytes in blood expressed the CCL2-receptor CCR2 and aberrant CD163<jats:sup>+</jats:sup>and immature phenotypes. Extensive accumulation of CD163<jats:sup>+</jats:sup>monocyte/macrophages within alveolar spaces in COVID-19 lung autopsies suggested recruitment from circulation. Our findings provide evidence that COVID-19 pathogenesis is driven by respiratory immunity, and rationale for site-specific treatment and prevention strategies.</jats:p>

Journal

  • medRxiv

    medRxiv 2020-10-19

    Cold Spring Harbor Laboratory

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