Power of the Classical Twin Design Revisited: II Detection of Common Environmental Variance

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<jats:title>Abstract</jats:title><jats:p>We expand our previous deterministic power calculations by calculating the required sample size to detect C in ACE models. The theoretical expected value of the maximum log-likelihood for the AE model was derived using two optimisation methods and these gave near-identical results. Theoretical predictions were verified by computer simulation and the results agreed very well. We have developed a user-friendly web-based tool, TwinPower, to perform power calculations to detect either A or C for the classical twin design. This new tool can be found at <jats:uri xmlns:xlink="http://www.w3.org/1999/xlink" xlink:type="simple" xlink:href="http://genepi.qimr.edu.au/cgi-bin/twinpower.cgi">http://genepi.qimr.edu.au/cgi-bin/twinpower.cgi</jats:uri></jats:p>

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