Antibody-Sensitive Renin of Adrenal and Resistance Vessels is Markedly Elevated in Spontaneously Hypertensive Rats
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- Mitsuhide Naruse
- 1Department of Biochemistry and Hypertension Center, Vanderbilt University, Nashville, TN, U.S.A.
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- Tadashi Inagami
- 2Department of Biochemistry and Hypertension Center, Vanderbilt University, Nashville, TN, U.S.A.
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説明
<jats:p>1. Three-week-old spontaneously hypertensive rats (SHR) showed markedly elevated specific renin activity in the adrenal and the mesenteric vessels compared with control Wistar-Kyoto (WKY)rats.</jats:p> <jats:p>2. In 17-week-old SHR with established hypertension, adrenal renin remained markedly elevated over that of WKY rats, whereas no significant difference was observed in renin of the mesenteric vessels.</jats:p> <jats:p>3. The specific renin activity of the aorta showed no significant difference compared with that of WKY rats at 3 or 17 weeks of age.</jats:p> <jats:p>4. These results suggest possible involvement of adrenal and vascular renin in the pathogenesis of hypertension in SHR.</jats:p>
収録刊行物
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- Clinical Science
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Clinical Science 63 (s8), 187s-189s, 1982-10-01
Portland Press Ltd.