Phosphoribosylpyrophosphate synthetase (<i>PRS</i>): A new gene family in <i>Saccharomyces cerevisiae</i>

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<jats:title>Abstract</jats:title><jats:p><jats:italic>Saccharomyces cerevisiae</jats:italic> contains at least four <jats:italic>PRS</jats:italic> genes, all of which have been cloned and sequenced. Each of the four derived amino acid sequences have more than 60% similarity to the corresponding polypeptides of man, rat, <jats:italic>Escherichia coli</jats:italic> and <jats:italic>Salmonella typhimurium</jats:italic>. The <jats:italic>PRS1</jats:italic> gene maps on chromosome XI, <jats:italic>PRS2</jats:italic> on chromosome V, <jats:italic>PRS3</jats:italic> on chromosome VIII and <jats:italic>PRS4</jats:italic> on chromosome II. One member of this gene family, <jats:italic>PRS1</jats:italic>, contains a region of non‐homology (NHR) shown by cDNA cloning and sequencing not to be an intron. The results presented here suggest that the presence of this NHR is not detrimental to the function of the gene. To date the possibility of protein splicing can be neither proven nor disputed. The sequences submitted to the EMBL data library are available under the following accession numbers: <jats:italic>PRS1</jats:italic> (X70069), <jats:italic>PRS2</jats:italic> (X74414) and <jats:italic>PRS3</jats:italic> (X74415).</jats:p>

Journal

  • Yeast

    Yeast 10 (8), 1031-1044, 1994-08

    Wiley

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