Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes

  • Nelly Rivera-Yañez
    Lab. Inmunobiología (L-321), UNAM FES Iztacala, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico
  • Mario Rodriguez-Canales
    IPN, Escuela Nacional de Ciencias Biológicas, Av. Wilfrido Massieu, Gustavo A Madero, 07738 Ciudad de México, Mexico
  • Oscar Nieto-Yañez
    Lab. Inmunobiología (L-321), UNAM FES Iztacala, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico
  • Manuel Jimenez-Estrada
    Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacán, DF, Mexico
  • Maximiliano Ibarra-Barajas
    UBIMED, UNAM FES Iztacala, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico
  • M. M. Canales-Martinez
    Lab. Farmacognosia, UBIPRO, UNAM FES Iztacala, Carrera Biología, Tlalnepantla, MEX, Mexico
  • M. A. Rodriguez-Monroy
    Lab. Inmunobiología (L-321), UNAM FES Iztacala, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico

抄録

<jats:p>Propolis is a bee-collected natural product that has been proven to have various bioactivities. This study tested the effects of a Mexican propolis on streptozotocin-induced diabetes mellitus in a murine model. The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the loss of body weight in diabetic mice. EEPCh increased plasma insulin levels in STZ-diabetic mice, whereas, in untreated diabetic mice, there was no detection of insulin. EEPCh had a high antioxidant capacity (SA<jats:sub>50</jats:sub> = 15.75 <jats:italic>μ</jats:italic>g/mL), which was directly related to the concentrations of total phenols (314 mg GAE/g of extract) and flavonoids (6.25 mg QE/g of extract). In addition, increased activities of the enzymes superoxide dismutase, catalase, and glutathione peroxidase were observed in diabetic mice treated with EEPCh. Compounds such as pinocembrin, quercetin, naringin, naringenin, kaempferol, acacetin, luteolin, and chrysin were identified by HPLC-MS analysis. This investigation demonstrated that propolis of Chihuahua possesses hypoglycaemic and antioxidant activities and can alleviate symptoms of diabetes mellitus in mice. These effects may be directly related to the chemical composition of propolis, as most of the compounds identified in propolis are reportedly active in terms of the different parameters evaluated in this work.</jats:p>

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