Structure and Function in the Nucleus

DOI Web Site 13 Citations
  • Angus I. Lamond
    A. I. Lamond is in the Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, UK. W. C. Earnshaw is in the Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK.
  • William C. Earnshaw
    A. I. Lamond is in the Department of Biochemistry, University of Dundee, Dundee DD1 4HN, Scotland, UK. W. C. Earnshaw is in the Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK.

Description

<jats:p>Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.</jats:p>

Journal

  • Science

    Science 280 (5363), 547-553, 1998-04-24

    American Association for the Advancement of Science (AAAS)

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