Synthesis of Potentially Antineoplastic Derivatives of N‐[<i>N</i>‐(2‐Chloroethyl)‐<i>N</i>‐nitrosocarbamoyl]amino Acids

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<jats:title>Abstract</jats:title><jats:p>The synthesis of <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>‐nitrosocarbamoyl]amino acids and their anilides, congeners of <jats:italic>N</jats:italic>‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>‐nitrosoureas, as potential antineoplastic substances is reported. <jats:italic>N</jats:italic>‐[<jats:italic>N</jats:italic>‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>‐nitrosocarbamoyl]amino acids are prepared by reaction of amino acids with <jats:italic>N</jats:italic>‐(2‐chloroethyl)‐<jats:italic>N</jats:italic>‐nitrosocarbamoyl azide. Corresponding anilides and toluidides are obtained by condensation of the primary reaction products with aniline and toluidine using dicyclohexylcarbodiimide (DCC).</jats:p>

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